Ben O'Shaughnessy's group combines mathematical and computational modeling, data analysis, image analysis and experimentation to investigate fundamental machineries used by living cells in health and disease. Our research is tightly integrated with collaborative experimental work.
Neurotransmission, neurotransmitter release, other secretion processes
We study neurotransmission and the machinery that releases neurotransmitters at neuronal synapses in the brain. This remarkable machinery achieves the millisecond temporal resolution required for neural circuits to encode information for cognition, sensation and coordinated motor activity. Its misregulation is associated with neurodegenerative and neurodevelopmental disorders. Similar mechanisms govern secretion of other essential bioactive compounds, including hormones such as insulin, cytokines in the immune system and enzymes.
Mechanics of cell division, mechanosensing
We investigate one of life’s most essential force-generating machines, the actomyosin contractile ring that divides cells at the end of the cell cycle during cytokinesis. Cell division propagates the genome and allows organisms to grow and repair, and its misregulation is the essential feature of cancer. Related interests in mechanobiology are the mechanisms of mechanosensing and remodeling in the actomyosin cytoskeleton and regulation of cell wall growth in cell walled organisms.
August 27, 2018
Roberto Alonso-Matilla joins our group as a postdoc. Welcome Roberto!
July 15, 2018
Nadiv Dharan joins our group as a postdoc.
Welcome to Nadiv!
July 8, 2018
Jerome Petit-Jacques is a new Senior Technician in our group, jointly with Clarissa Waites' lab, Dept. Neuroscience.
Welcome to the group Jerome!
April 18, 2018
The award initiates an exciting new joint investigation of synaptic release with Clarissa Waites' lab in Neuroscience.
December 08, 2017
Sathish modeled the cytokinetic contractile ring and control of neurotransmitter release.
Congratulations Dr. Thiyagarajan!
December 07, 2017
Joseph built a realistic 3D simulation of the contractile ring that divides living cells.
October 16 , 2017
Egor Antipov joins our research group to perform his doctoral research.
October 16 , 2017
Rui Su joins our research group to perform his doctoral research.
Welcome to Rui!
May 03, 2017
Brett combined experiment and modeling to study how influenza virus enters cells.
Congratulations Dr. Alcott!
© O'Shaughnessy Group 2018